Personalized medicine for rheumatic disease patients. Treatment options include various types of medications: conventional synthetic disease-modifying anti-rheumatic drugs, biological therapies and targeted synthetic small molecules. However, no single therapeutic mode is affective for all patients, and there are no predictive biomarkers for most drugs. The identification of such biomarkers would greatly assist in differentiating between individuals who are likely to benefit from a specific therapy from those who are not. Our ongoing project is designed to apply ex-vivo testing methods for response to a variety of anti-rheumatic drugs.

New approaches for resolution of synovial inflammation. The current clinical treatment of synovial inflammation relies upon intra-articular administration of glucocorticoid (GCs) injections directly to the joints. GCs may be associated with side effects, such as cartilage loss. Novel alternative approaches to manage inflammatory arthritis remain an unmet need of our lab. We investigate novel therapeutic approaches to restore the inflammatory process in the synovium.

Personalized medicine for rheumatic disease patients. Treatment options include various types of medications: conventional synthetic disease-modifying anti-rheumatic drugs, biological therapies and targeted synthetic small molecules. However, no single therapeutic mode is affective for all patients, and there are no predictive biomarkers for most drugs. The identification of such biomarkers would greatly assist in differentiating between individuals who are likely to benefit from a specific therapy from those who are not. Our ongoing project is designed to apply ex-vivo testing methods for response to a variety of anti-rheumatic drugs.

2) New approaches for resolution of synovial inflammation. The current clinical treatment of synovial inflammation relies upon intra-articular administration of glucocorticoid (GCs) injections directly to the joints. GCs may be associated with side effects, such as cartilage loss. Novel alternative approaches to manage inflammatory arthritis remain an unmet need of our lab. We investigate novel therapeutic approaches to restore the inflammatory process in the synovium.