Development of novel digital approaches to hematology diagnostics. These include image analysis of peripheral blood and bone marrow specimens, digitalization of routine laboratory processes, data mining from hematological specimens and their processing. 2. Big data analysis of laboratory tests in the fields of benign and malignant hematology and blood coagulation disorders. 3. Dissection of signal transduction pathways in malignant B-cells, and mechanisms-based development and improvement of immune therapeutics.